Chemogenetic and Optogenetic Manipulations of Microglia in …
WEBSimilarly, optogenetic tools allow for microglial manipulation via the activation of artificially expressed, light-sensitive proteins. Chemo- and optogenetic manipulations of microglia in vivo are powerful in interrogating microglial function in chronic pain.
Microglial optogenetics triggers chronic pain in mice
WEBApr 7, 2021 · “Our study shows that microglial activation is sufficient to trigger chronic pain behaviours and that calcium and IL-1β act downstream of microglial ReaChR,” states Wu.
Chemogenetic Manipulation of Microglia Inhibits ... - SSRN
WEBJun 25, 2020 · Our results demonstrate that microglial Gi DREADD reduces neuroinflammation, synaptic function and neuropathic pain after SNT. Thus, chemogenetic approaches provide a potential opportunity for interrogating microglial function and neuropathic pain treatment.
Chemogenetic approaches reveal dual functions of microglia in
WEBMay 31, 2023 · RNAseq analysis revealed that prolonged activation of Gi-Dreadd interferes with interferon β signaling and microglia proliferation. Thus, our findings highlight the importance of microglial activation not only during status epilepticus (SE) but also within later seizure induced pathology.
Chemogenetic approaches reveal dual functions of microglia in …
WEBMicroglia are key players in maintaining brain homeostasis and exhibit phenotypic alterations in response to epileptic stimuli. However, it is still relatively unknown if these alterations are pro- or anti-epileptic. To unravel this dilemma, we employed chemogenetic manipulation of microglia using t ….
Chemogenetic manipulation of microglia inhibits neuroinflammation …
WEBUsing in vivo spinal cord recording, we found that activation of microglial Gi DREADD attenuated synaptic transmission following SNT. Our results demonstrate that microglial Gi DREADD reduces neuroinflammation, synaptic function and neuropathic pain after SNT.
Microglial process dynamics enhance neuronal activity by …
WEBNov 9, 2022 · Microglial ablation or loss of microglial β2-adrenergic receptors prevent post-anesthesia neuronal hyperactivity. Together, our study demonstrates a previously unappreciated function of microglial process dynamics, which allow microglia to transiently boost neuronal activity by physically shielding inhibitory inputs.
Lab Photos | McGovern Medical School
WEBLab Photos. The first official photo for the Wu Lab at UTHealth Houston (Jul 2024) Wu lab at Mayo last gathering (Mar 2024). Thank you all, and look forward to the next chapter of Wu lab at UTHealth Houston! Wu lab celebrates Fiona’s PhD defense.
Lab News | McGovern Medical School
WEBAug 5, 2024 · Wu lab had a farewell party for Min-Hee. Min-Hee will start her independent research program as an Assistant Professor at Chonnam National University, South Korea. Thank you and wish you all the best, Min-Hee!
Junting LIU | University at Buffalo, The State ... - ResearchGate
WEBMin-Hee Yi Long-Jun Wu Microglia are an exquisitely tiled and self-contained population in the CNS that do not receive contributions from circulating monocytes in the periphery.