Santa Ana is the second largest city in El Salvador, after the capital of San Salvador. It is located 64 kilometers northwest of San Salvador, the c…Santa Ana is the second largest city in El Salvador, after the capital of San Salvador. It is located 64 kilometers northwest of San Salvador, the capital city. Santa Ana has approximately 277,264 inhabitants and serves both as the capital of the department of Santa Ana and as the municipal seat for the surrounding municipality of the same name. For its administration the municipality is divided into 35 colonias and 318 small villages.
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