San Francisco 49ers running back Isaac Guerendo is expected to play Monday night against the Detroit Lions, according to ESPN ...

Last time the 49ers faced Detroit, they won but also gave up 31 points. And that was in the NFC Championship Game last season ...

With the exception of David Montgomery, the Lions had perfect practice attendance Saturday among players on the active roster ...

The Detroit Lions visit the San Francisco 49ers on Monday at 8:15 p.m. ET, in a matchup featuring a pair of the best ...

The 49ers are eliminated from the playoffs. But don't tell Kittle or Samuel that, with both studs having two of their best ...

Best streaming services for Lions vs. 49ers. Detroit Lions vs. San Francisco 49ers will be aired locally in the Bay Area. It ...

Detroit's defensive injuries will probably catch up to them in the postseason, but the 49ers don't look to have enough in the ...

The Detroit Lions and the San Francisco 49ers will go head to head for Monday Night Football this week, but tight end George Kittle is kicking things off with nothing but love, at least as it relates ...

It's a recipe that's as versatile as it is simple. Pair it with tortilla chips, quesadillas, tacos — whatever you want on ...

San Francisco 49ers face a daunting Week 17 test against Detroit Lions with injuries threatening their ability to compete.

San Francisco 49ers top scorers look to capitalize on opportunities early against Detroit Lions stout defense.

Last season, Detroit squandered a 17-point halftime advantage to the 49ers, who rallied to win the NFC Championship game. The Lions were forced to walk off the field in disappointment, and now have an ...