An equal mix of MLS and Liga MX teams will face off in the quarterfinals of the Concacaf Champions Cup, which kicks off on Tuesday with first leg action as the last eight teams left have their eyes set on North America's top club prize.

The Investec Champions Cup returns with the last-16 on Friday and BBC Sport explores five things to look out for across the weekend.

Saracens boss Mark McCall has defended the decision to rest the club’s England stars from the Investec Champions Cup last-16 clash with Toulon. None of Maro Itoje, Jamie George, Tom Willis, Ben Earl or Elliot Daly will feature in the south of France as they serve a mandatory rest-week after their Six Nations exertions.

The Vancouver Whitecaps clash with Liga MX side Pumas UNAM in the first leg of the quarterfinal round of the 2025 CONCACAF Champions Cup.

The Galaxy keep their Liga MX opponent from scoring an important away goal and give themselves a chance to escape the two-leg CONCACAF series next Tuesday in Mexico.

LAFC made the Champions Cup finals in 2020 and 2023 and beat the Columbus Crew 4–2 on aggregate in the Round of 16 last month. Denis Bouanga, the MLS Golden Boot winner in 2023 and co-runner-up with Messi and Luis Suarez last season, scored three of L.A.’s four goals against the Crew.

That in itself is a debatable criterion, as neither LAFC nor Club América has won a tournament that would qualify them for the Club World Cup. Now, the winner of the playoff will play for a $125 million prize — the tournament winner’s bounty as part of the $1 billion pot.

Lionel Messi and Inter Miami CF travel cross-country Wednesday night for a matchup with LAFC in the first leg of their Concacaf Champions Cup semifinal.

Inter Miami travel west midweek to face LAFC in the Concacaf Champions Cup quarterfinals.The first leg takes place at BMO Stadium in Los Angeles. The quarterfinal is the only matchup between two Major League Soccer sides.