Cleveland Guardians right-hander Tanner Bibee was scratched from his scheduled Opening Day start just hours before he was slated to take the mound against the Kansas City Royals after coming down with food poisoning. Bibee's start will instead go to veteran Ben Lively.

Steven Kwan knocked in the go-ahead run in the 10th on a double that scored Brayan Rocchio. Designated hitter Kyle Manzardo hit a key two-run homer to give the Guardians a 4-3 lead in the sixth inning. Manzardo also came through with a two-run double in the 10th to finish with three hits and four RBIs.