Researchers at Indiana University Bloomington have uncovered previously hidden steps of a gene silencing process used to combat viruses and other would-be genome invaders. The new findings, published ...

Human Argonaute 1 protein (cyan) bound to let-7 microRNA (magenta). Ago protein family plays a role in RNA silencing processes. Cartoon model with semi-transparent surface. Shutterstock | petarg ...

Argonaute proteins function in small interfering RNA (siRNA)-mediated cytoplasmic RNA interference (RNAi). But Guang et al. now describe a function for the Caenorhabditis elegans Argonaute protein ...

MicroRNAs (miRNAs) perform critical functions in normal physiology and disease by associating with Argonaute proteins and downregulating partially complementary messenger RNAs (mRNAs). Here we use ...

The Argonaute (Ago) enzyme complex plays a critical role in DNA and RNA target cleavage for a process known as RNA silencing in prokaryotic and eukaryotic cells, making them a target for future ...

But the protein's full set of functions and how they relate to ALS and FTD have never been clear. Wang and his colleagues began their study with the discovery that FUS binds to a protein called ...

Greg Hannon's group at Cold Spring Harbor Laboratory was one of many labs scrambling to identify Slicer, the enzyme doing the cutting in RNA-mediated interference. Using biochemical mutagenesis, in ...

Aedes aegypti mosquitoes transmit viruses that are responsible for a significant global public health burden such as Zika, dengue, and yellow fever. Now, researchers found that an Ae. aegypti protein, ...

Restriction enzymes are essential tools for recombinant DNA technology that have revolutionized modern biological research; however, they have limited sequence specificity and availability. The ...

Victor Ambros receives funding from the U.S. National Institutes of Health. The Conversation Weekly podcast caught up with Victor Ambros from his lab at the UMass Chan Medical School to learn more ...

COLUMBUS, Ohio – Scientists have unraveled the step-by-step activation process of a protein with a deep evolutionary history in all domains of life, opening the door to harnessing its functions for ...