Idarubicin cardiotoxicity: a retrospective study in acute myeloid leukemia and myelodysplasia. Initial phase I evaluation of the novel thymidylate synthase inhibitor, LY231514, using the modified ...

These factors could provide a scientific basis for consistency evaluations of the quality and efficacy of insulin biosimilars, study authors wrote. Factors that may affect the bioequivalence of test ...

Adam Hayes, Ph.D., CFA, is a financial writer with 15+ years Wall Street experience as a derivatives trader. Besides his extensive derivative trading expertise, Adam is an expert in economics and ...

Schizophrenia is a severe psychiatric disorder with a diverse clinical presentation, including both positive symptoms, such as hallucinations and delusions, and negative symptoms, such as depression ...

The US Food and Drug Administration (FDA) finalized two guidances on studies on 28 May to assist sponsors in establishing bioequivalence (BE) for new and generic drugs. One focuses on BE studies with ...

A new guideline for conducting bioequivalence studies was adopted by the CPMP in January and it becomes fully effective as of August 2010. A new guideline 1 for conducting bioequivalence studies was ...

The updated FDA guidance covers orally disintegrating tablets, sublingual tablets and transdermal delivery. (FDA) () The FDA has updated its draft guidance on bioequivalence studies with fresh advice ...

Over 80% of U.S. drug prescriptions are for generic medicines. 1 Such medicines are an important part of the medical system, helping to alleviate drug shortages and improve access to affordable ...

Small variations in formulation can affect bioequivalence. However, with simultaneous dissolution-permeation testing, true absorption potential is revealed. Image Credit: Mentor57/Shutterstock.com ...

Topical pharmaceutical products usually take the form of lotions, creams, gels, ointments, or pastes and are used to deliver locally-acting drugs to their sites of action. Local anesthetics, ...