The complement system in teleost fish constitutes a cornerstone of innate defence, integrating classical, lectin and alternative activation routes to eliminate pathogens and shape inflammatory ...

The complement cascade, traditionally appreciated for its role in innate immunity, has emerged as a pivotal regulator of bone repair. Activation of complement components generates anaphylatoxins such ...

A new review by Dr. Ruyuan Wang and an international team of researchers explores the complex interactions between the innate and adaptive immune systems, shedding light on regulatory mechanisms in ...

Among people with sickle cell disease—an inherited blood disorder—acute chest syndrome (ACS) is the leading cause of death. The condition is the result of red blood cells becoming stiff, sticky, and ...

Researchers have shown that innate immune training, also known as trained immunity (TRIM), leads to aggravated bone loss in experimental models of periodontitis and inflammatory arthritis. Clinical ...