Ionization spectroscopy has emerged as a pivotal technique in elucidating the energy landscapes and structural intricacies of conformational isomers. This method capitalises on the precise measurement ...

Understanding the thermodynamic basis of ligand recognition by G-protein-coupled receptors (GPCRs), especially in terms of ...

Researchers analyzed the thermodynamics of doxepin binding to the histamine H1 receptor. The findings highlight the ...

The findings show that considering conformational constraints and flexibility in designing ligands with optimized thermodynamic properties can lead to improved drugs with higher selectivity.

G-protein-coupled receptors (GPCRs) are one of the largest families of cell surface proteins in the human body that recognize hormones, neurotransmitters, and drugs. These receptors regulate a wide ...

G-protein-coupled receptors (GPCRs) are one of the biggest groups of cell surface proteins in the human body, recognizing hormones, neurotransmitters, and drugs.