To generate a tissue specific knockout mouse, researchers breed a mouse bearing a Cre transgene under a tissue- or cell-type specific or inducible promoter (A) with a homozygous floxed mouse (B). The ...

Early stage pancreatic lesions in Pdx1-Cre; LSL-Kras; Ink/Arf lox / lox animals. (A) A low-grade PanIN lesion. (B) A low-grade preinvasive ductal lesion. (C) A high-grade preinvasive ductal lesion. (D ...

The scientists' designed special mice for their experiments using a gene-replacement technique known to researchers as Cre-Lox recombination. These genetically engineered lab mice developed more ...

We have used powerful conditional “gene knockout” techniques involving the cre/lox recombinase system to create mice that lack neurotrophic factors only in a specific tissue. This allowed us to ...

A current search for Cre recombinase transgenic mice in Medline yields over 900 publications, more than half of which were published in 2003 or later. In view of this popularity, it appears ...