Researchers have identified a dual therapeutic strategy that combined inhibition of a key SARS-CoV-2 viral enzyme with suppression of a host inflammatory pathway, with preclinical evidence that ...

Systemic sclerosis is an autoimmune disease that primarily causes inflammation of the skin, as well as internal organs such as the lungs and heart. It is considered a rare disease, and little is yet ...

Autoimmune diseases stem from a complicated interplay of immune dysregulation, characterized by chronic inflammation and the loss of self-tolerance. Cytokines are central to these processes. These ...

When cancer cells die, macrophages consume them and produce inflammatory cytokines. This activates JAK and STAT proteins in living cancer cells, enabling them to produce their own Upd3 and creating a ...

Cytokines are key to immune regulation. Their extensive impact on human biology and disease has led to their long-term therapeutic use in treating cancer and a range of other diseases. Interleukin-2 ...

Patients with chronic kidney disease (CKD) stage G3 showed distinct inflammatory cytokine profiles that correlated with disease progression. Specific cytokine clusters were associated with a faster ...

The transition from preclinical development to clinical trials is a critical, yet high-risk stage in drug development, with approximately 89% of drugs failing to progress through all phases of ...

Clonal hematopoiesis (CH), the benign clonal expansion of hematopoietic stem cells, is often caused by somatic sequence variations in genes associated with hematologic malignancies. Over the past ...