Sarah J. Aitken is at the Center of Molecular and Cellular Oncology, Yale Cancer Center, New Haven, Connecticut 06511, USA, and in the Department of Pathology, Yale School of Medicine, New Haven. Read ...

Our DNA is constantly being packed and unpacked. And there is a good reason for this: depending on its packing state, it performs different functions in the cell nucleus. For most of its life – this ...

Scientists have elucidated the molecular mechanism by which LEM-3 cuts DNA bridges during cytokinesis. If DNA bridges persist between chromosomes during cell division, chromosomes are abnormally ...

Many cellular functions in the human body are controlled by biological droplets called Liquid-Liquid Phase Separation (LLPS) droplets. These droplets, made of soft biological materials, exist inside ...

“Our lab is generally interested in discovering and characterizing previously unknown or poorly understood factors that are essential for genome maintenance. This is particularly important in the ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...

Working with human breast and lung cells, Johns Hopkins Medicine scientists say they have charted a molecular pathway that can lure cells down a hazardous path of duplicating their genome too many ...

Researchers at the Centre for Genomic Regulation (CRG) reveal that metabolic enzymes known for their roles in energy production and nucleotide synthesis are taking on unexpected "second jobs" within ...

A time-delay circuit enables precise control over the division of synthetic DNA droplets, which mimic biological Liquid-Liquid Phase Separation (LLPS) droplets found in cells. By utilizing a ...