ESPN announced a major change for the Week 16 showdown between the San Francisco 49ers and Indianapolis Colts.

The 49ers are fighting for their spot in the NFC playoffs this season. Here's where they stand heading into Week 14 of the 2025 season.

The San Francisco 49ers are signing the New England Patriots’ 2024 fourth-round pick, Javon Baker, to the practice squad, per ESPN’s Jeremy Fowler. Baker appeared in seven games as a rookie and only registered one reception.

Most Wednesdays, ESPN P.R. posts a tweet boasting about the audience generated by the NFL game televised two nights earlier. This year, the habit

Eric Kendricks came close to joining the Baltimore Ravens before ultimately declining their offer. The San Francisco 49ers are now launching his NFL comeback. The 33-year-old is giving the Niners a try — earning his chance to be elevated from the practice squad. S.F. lured in Kendricks to close out November amidst some notable defensive injuries.

Sanders is starting in Week 13 against the San Francisco 49ers, and Garrett gets to go up against Brock Purdy and a shaky 49ers offense in what's projected to be rainy and windy c

Christian McCaffrey is making NFL history for the San Francisco 49ers with 1,655 scrimmage yards and top RB receptions through Week 13 of 2025.

NFL survivor pool strategy, predictions and picks for ESPN Eliminator Challenge Week 15, including teams to pick or save for later.

Levi's Stadium in Santa Clara, California, will be the site of Super Bowl LX in February. It's also the stage for the latest edition of ESPN's "Monday Night Football." Fresh off a franchise-record performance against the Atlanta Falcons, Bryce Young leads ...

Using their Football Power Index model, ESPN gives the Rams the best chances of winning it all at 13.8 percent. Matthew Stafford and company have a 40-percent chance alone of reaching the NFC Championship Game, and a 23.6 percent chance of winning the conference.

The Chicago Bears and San Francisco 49ers are among several D/ST units to stream in Week 15 of fantasy football.