The central thesis of TLPath is that telomere length can be determined from cell and tissue shape. Trained on more than 5,000 whole-slide images across 919 individuals and 18 organs, TLPath uses ...
Different variants of a gene, known as isoforms, can be transcribed and translated at varying levels within a cell or tissue. These isoforms are commonly a result of alternative splicing, which ...
Scientists at Sanford Burnham Prebys Medical Discovery Institute have developed a new computational tool, TLPath, that can infer changes occurring at the ends of chromosomes—the telomeres—by detecting ...
Mitochondrial enzymatic activity and mtDNA density measures display low between-tissue correlations across 22 tissues from 27 mice. A long-standing assumption is that mitochondrial energy capacity is ...
A Yale research team has created a new imaging technique that reveals the hidden connections between aging, disease, and genetic activity in human cells. Using a novel machine learning approach, the ...
A new research paper was published in Aging (Aging-US) on January 3, 2025, in Volume 17, Issue 1, titled "Characterization of DNA methylation clock algorithms applied to diverse tissue types." ...
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