A variety of abnormal RNAs and peptides result from repeats in the C9ORF72 gene, the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. Which of these funky ...
Two new mouse models for amyotrophic lateral sclerosis and frontotemporal dementia display classic pathological signs of the C9ORF72 repeats they carry—but no sign of neurodegeneration. The models, ...
Many patients with amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD) harbor the (G4C2)n pathogenic repeat expansion in the C9orf72 gene, which leads to aggregating dipeptide ...
Figure 1: Interaction of conserved glycine-alanine pairs in TM3 of MscS. Figure 3: Introduction of mutations close to the seal reduces channel conductance. Figure 5: Structure of the MscS channel pore ...
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