Researchers from the Icahn School of Medicine at Mount Sinai have introduced KiNet, an interactive web portal designed to explore kinase-substrate interactions in human cellular systems. These ...
Hypertrophic cardiomyopathy (HCM) is the most common hereditary heart disease. It causes the left ventricle to thicken, the ...
Nuclear speckles are non–membrane-bound organelles known as storage sites for messenger RNA (mRNA) processing and splicing factors. More recently, nuclear speckles have also been implicated in ...
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Kinase enzymes exist throughout tree of life—those found in bacteria may be vulnerable targets for new antibiotics
Enzymes known as kinases play a critical role in cell growth, metabolism and signaling in a multitude of organisms across the tree of life—from algae to helminths to mammals. Now, scientists have ...
Lei Wang, Jun Young Park, Fengming Liu, Kris M. Olesen, Shirui Hou, Jamy C. Peng, Jordan Infield, Anna C. Levesque, Yong-Dong Wang, Hongjian Jin, Yiping Fan, Patrick ...
More than two decades of effort went into a project that has now revealed the structure of a crucial signaling molecule, opening the door to new and better drugs for some cancers. For more than 20 ...
The protein kinase CK2 is involved in a wide range of biological processes and cellular functions, including inflammatory responses and pathologies associated with inflammation. Also, its aberrant ...
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