Gluconeogenesis is an important component of maintaining energy homeostasis; however, excessive gluconeogenesis is implicated in the development of type 2 diabetes mellitus (T2DM). Two recent papers ...

Designing combination therapies based on the different factors involved in the control of glucose synthesis by the liver could be a more effective strategy to address the treatment of the disease. One ...

One of the most confusing aspects for patients with type 2 diabetes mellitus is that they have high fasting glucose levels. This is because in these insulin-resistant patients, glucose production by ...

Despite improvements in their nutritional management, most premature and low birth weight infants have experienced growth faltering by discharge. Many remain small to adulthood and are at an increased ...

Rita Basu holds the Endowed Professorship in Diabetes Science in the UAB Department of Medicine Division of Endocrinology, Diabetes, and Metabolism and is a senior scientist in the UAB Comprehensive ...

Glucagon increases the production of glucose by increasing glycogenolysis and gluconeogenesis in the liver, and by reducing glycogenesis and glycolysis. The release of glucagon in response to food ...