We have identified a heptapeptide with high affinity to rheumatoid arthritis–associated class II major histocompatibility (MHC) molecules. Using a model of its interaction with the class II binding ...

Soluble extracellular protein antigens are notoriously poor stimulators of CD8 + cytotoxic T-lymphocyte (CTL) responses, largely because these antigens have inefficient access to an endogenous ...

In a recent article posted to the bioRxiv* preprint server, researchers demonstrated the sarbecovirus open reading frame 7a (ORF7a)-induced hindrance of the antigen presentation by the major ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 82, No. 18 (Sep. 15, 1985), pp. 6265-6267 (3 pages) Studies on the survival of skin-specific antigen ...

The effect of anti-Lyt2 on the generation of helper T-cell function and on cytotoxic effects specific for subregions of the major histocompatibility complex (MHC) was determined. The addition of ...

Immunopeptidomics is an emerging and rapidly evolving field that focuses on the identification of peptides presented by major ...

Major histocompatibility complex class II (MHC-II) molecules play a critical, yet historically overlooked, role in tumor immunity.

By Tarun Sai Lomte New evidence shows that human M cells act as fully fledged antigen-presenting cells, processing and presenting gluten peptides through a dendritic cell-like pathway that may shape ...