That said, both minocycline and doxycycline can interact with the following medications: There are a few differences to note: Isotretinoin, an acne medication, should not be taken with minocycline.

One group was given minocycline in escalating doses of up to 400 mg per day for 9 months, and the other received placebo. By use of the revised ALS Functional Rating Scale, the researchers showed ...

A low-dose (40 mg) modified formulation of minocycline hydrochloride (DFD-29) was better tolerated and more effective than doxycycline and placebo in patients with moderate to severe ...

but not to minocycline (Eady et al., 1993). One study of patients with moderate acne showed that a submicrobial dose of doxycycline, 20 mg tablets twice a day, reduced total lesion counts ...