That said, both minocycline and doxycycline can interact with the following medications: There are a few differences to note: Isotretinoin, an acne medication, should not be taken with minocycline.

but not to minocycline (Eady et al., 1993). One study of patients with moderate acne showed that a submicrobial dose of doxycycline, 20 mg tablets twice a day, reduced total lesion counts ...