Check out the best pick 'em plays, optimal lineups and promos for DraftKings, Betr, Underdog and more for NFL Week 2.

Before setting your NFL DFS lineups on daily Fantasy football sites like DraftKings and FanDuel for this matchup, you NEED to see what Mike McClure has to say. McClure is a legendary professional DFS player with more than $2 million in career winnings.

SportsLine's model enters Week 2 of the 2026 NFL season on a 53-39 run on top-rated picks dating back to 2024. One of its favorite picks at the best betting apps is the Buccaneers (-8.5, 40.5) covering versus Cleveland, which cashes well over 50% of the time. You can find the model's picks for every NFL Week 2 game here .

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Josh Allen not only got his first career overtime win, but he also won the first time when rushing for 100-plus yards in a game.

Now, SportsLine's NFL DFS Optimizer has turned its attention to Sunday's 2026 NFL Week 2 schedule and just locked in its top daily Fantasy football lineups. You can only see its optimal lineups at SportsLine.