The San Francisco 49ers defeated the New Orleans Saints in Week 2. How did it affect how Kyle Shanahan's team is being viewed in Week 3.

Find single game tickets to the San Francisco 49ers vs. Arizona Cardinals NFL Week 3 matchup on Sunday, September 21, 2025 at Levi's Stadium.

On Sept. 11, before taking on the Saints, NFL Network’s Ian Rapoport reported that Purdy is set to miss two to five weeks due to a “turf toe-like injury.” On the high end, that means he may not return until Week 7 against the Atlanta Falcons.

The San Francisco 49ers' starting offensive line may get a shakeup with a potential late-round NFL draft steal finding his way into that group.

The San Francisco 49ers opened practice Wednesday for Sunday’s game against the Arizona Cardinals with 10 players (six starters) on the injury report, eight of whom did not practice. Quarterback Brock Purdy, who missed Sunday’s game against the Saints, was limited.

After a couple of weeks into the season, the San Francisco 49ers stand at 2-0. However, injuries have struck the team immediately, just like last season. They've lost tight end Geo

It was dicey for San Francisco's defense, but it was Huff flying off the edge on fourth-and-2 who got home and knocked the ball away from QB Spencer Rattler for his first sack of the season. His sack also ensured the 49ers took home a victory and moved to 2-0 on the season.

We've put together a three-leg parlay featuring underdogs at Caesars Sportsbook for Week 3 of the 2025 NFL season

NFL Week 3 odds, picks, predictions, TV channel, streaming information for Sunday football game between the Arizona Cardinals and San Francisco 49ers.

After their Super Bowl run, the 49ers were forced to replace Greenlaw, who tore his Achilles against the Kansas City Chiefs. Rather than elevating Winters, San Francisco turned to longtime Falcon De’Vondre Campbell. Despite posting solid numbers, Campbell was abruptly released by the end of week 14.