Focusing on the schematic illustration in a, two DNA polymerase molecules are active at the fork at any one time. One moves continuously to produce the new daughter DNA molecule on the leading strand, ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 21 (May 24, 2016), pp. 5916-5921 (6 pages) DNA replication occurs semidiscontinuously due to the ...

Overview: My research career was devoted to helping to establish the central principals of cellular DNA replication, ranging from mechanisms of nucleotide biosynthesis to the complex interplay of ...

Half a century ago, scientists Jim Watson and Alexey Olovnikov independently realized that there was a problem with how our DNA gets copied. A quirk of linear DNA replication dictated that telomeres ...

Figure 1: Primer synthesis occurs concomitantly with DNA unwinding and synthesis. Figure 2: Priming loop: the primase domain maintains contact with the priming sequence during replication. Making ...