The ryanodine receptor isoform 1 (RyR1) is a large homotetrameric intracellular calcium channel of skeletal muscle. Its opening releases Ca 2+ stored in the sarcoplasmic reticulum (SR) into the ...

Rabbit skeletal muscle sarcoplasmic reticulum was treated with hydrogen peroxide, then RyR1 complex was isolated. The proteins in the complex were analysed by electrophoresis, Western blot and ...

Schematic representation of the mechanism leading to prolonged bleeding time due to RYR1 mutations. In normal conditions (left panel), early vasospasm occurring immediately after injury reduces ...

S5 mutations disrupt RyR1 channel function, influencing both channel activity and gating mechanisms. This impacts the release of calcium and affects muscle contractions, leading to severe muscle ...

A team of researchers has found that mutations in the calcium channel protein RyR1 that confer susceptibility to malignant hyperthermia make the protein hypersensitive to heat, which triggers ...

This is a preview. Log in through your library . Abstract Single-channel recordings are widely used to explore functional properties of ion channels. Typically, such recordings are performed at ...

Calcium-uptake and ATPase studies carried out on fragmented sarcoplasmic reticulum from muscle of patients with Duchenne dystrophy showed low initial and total calcium uptake, low ATPase activity and ...

The type 1 ryanodine receptor (RyR1) is an important calcium release channel in skeletal muscles essential for muscle contraction. It mediates calcium release from the sarcoplasmic reticulum, a ...