Herpes simplex virus partially liquefies the tightly packed, gel-like interior of human cell nuclei to copy itself faster, a new study shows. The research centers on how the nucleus of each human cell ...

Ongoing research aims to confirm the mechanism by which ICP4 fluidizes the nucleus, which could indicate specific targets to counter viral replication.

A research team at the University of Würzburg has deciphered another aspect of poxviral gene activation. They have revealed a unique viral mechanism: A molecular ring anchors the viral copying machine ...

Researchers identified how the poxvirus protein VITF-3 forms a molecular ring that clamps onto DNA with viral RNA polymerase, bending it by 90 degrees to initiate gene copying.

For the first time, scientists have been able to watch the flu virus live as it infects human airway cells. They developed a new technique which makes the viral genetic material light up under the ...

The re-transcribed DNA is then integrated into the genome of the host cell (Figure 2). This process requires the absence of the nuclear membrane and thus is restricted to the M-phase of proliferating ...

Transcription initiation and elongation of HIV-1 are critical processes regulating viral latency and activation. Despite these two processes playing essential roles in HIV-1 gene expression, how they ...

We have examined the effect of ribavirin on vesicular stomatitis virus (VSV) RNA synthesis using a cell-free transcription system. Our prior data indicated that ribavirin had little effect on primary ...

The technology, called the Viral-Engineered RNA-based Activation System (VERAS), hijacks the virus’s own replication machinery to switch on reporter or therapeutic genes precisely in infected cells.