A machine-learning method predicts whether a genetic variant is pathogenic and affects certain human tissues. The ...

How the hydrolytic activity of mitochondrial ATP synthase is modulated during brown adipose tissue (BAT) thermogenesis ...

K Heran Darwin is at New York University Grossman School of Medicine and a regular columnist for EMBO reports.

MDA5 is a critical cytoplasmic RNA sensor capable of triggering type I interferon pathways. This study shows that the E3 ...

It is boomtime for metabolism and metabolomics research. One hundred years after Otto Warburg put metabolism at the core of ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and ...

Human papillomavirus (HPV) and hyperactivated YAP1 form a YAP1-HPV oncogenic alliance to drive the malignant transformation ...

FAO is catalyzed by the mitochondrial trifunctional protein (MTP) and, if overloaded, generates ROS. ROS are boosted during ...

The gut microbiota and its functional metabolites play crucial roles in the development of intestinal fibrosis in patients ...

Co-expressing NPY and its inhibitory receptor Y2 in excitatory hippocampal cells allows inhibitory autoregulation of ...