The San Francisco 49ers will be without star running back Christian McCaffrey for a while. The 49ers are placing McCaffrey on injured reserve, a person familiar with the situation told USA TODAY ...

The San Francisco 49ers and Los Angeles Rams play on Sunday, Sept. 22, at SoFi Stadium in a game on the NFL Week 3 schedule. Which team will win the Week 3 NFL game? Check out these NFL Week 3 ...

A pressure-packed season for the San Francisco 49ers is already ratcheting up severely. The 49ers dropped a game to the upstart Minnesota Vikings for the second straight year on Sunday ...

The San Francisco 49ers picked up their first loss of the season, falling 23-17 to the Minnesota Vikings in Week 2. A special teams error, two turnovers (interception and fumble) and two turnovers ...

LATEST Sept. 14, 10:30 a.m. The San Francisco 49ers are placing Christian McCaffrey on injured reserve on Saturday, according to multiple reports. ESPN’s Adam Schefter and NFL Network’s Ian ...

The San Francisco 49ers and Minnesota Vikings play Sunday, Sept. 15, at U.S. Bank Stadium in a game on the NFL Week 2 schedule. Which team will win the Week 2 NFL game? The 49ers are a 5.5-point ...

Another star player on the 49ers has suffered a calf strain that will hold him out for a "couple weeks" per head coach Kyle Shanahan. The loss to the Minnesota Vikings is getting worse for the San ...

The San Francisco 49ers have one of the most well-built rosters in football. San Francisco made a run to the Super Bowl last season, although it ended up losing to the Kansas City Chiefs.

The San Francisco 49ers are going to be without reigning NFL Offensive Player of the Year Christian McCaffrey for at least the next month. San Francisco placed McCaffrey on short-term injured ...

The 49ers reportedly checked in on multiple potential replacements for Brandon Aiyuk in the wake of the uncertainty surrounding the wide receiver this offseason. Before San Francisco ended their ...