LOX depletion in SMCs did not influence systolic blood pressures during AngII infusion. Histological analyses indicated increased elastin breaks in SMC-LOX deficiency mice compared to control mice.

The Cre-lox recombination method orchestrates remarkable genetic manipulations that remain a gold standard for transgenic mice. A series of rodent experiments showed that even with abundant food and ...

Tissue-specific Cre recombinase often drives 'off-target' reporter activity in the male reproductive tract, suggesting the potential for inter-tissue RNA or protein trafficking in control of sperm ...

I used the Logitech Lift for a week, and learned that while vertical mice have their pros and cons, they aren’t for everyone.

We have created an MmuPV1-lox-Cre-lox plasmid which we deliver to the tail skin of reporter R26R-lox-STOP-lox-eYFP mice. Expression of self-deleting Cre from the plasmid results in recombination of ...

By breeding transgenic mice with two types of Cre mice, we successfully induced the heart-specific overexpression of TNC in both cases. Methods Generation of the Mutant Strain We utilized the Cre/loxP ...

One of the systems used for conditional gene inactivation is Cre/lox. "It is the gold standard for the conditional gene inactivation in mice but over time has also become quite important in other ...

Most analysis of gene function in biomedical research relies on the use of Cre-lox technology. Since its introduction in 1994, this technology has revolutionized biomedical science because it ...

Here, we develop mice in which we have specifically inactivated both insulin receptors (IRs) and IGF-1 receptors (IGF1Rs) in the hippocampus (Hippo-DKO) or central amygdala (CeA-DKO) by stereotaxic ...