Xofluza is a cap-endonuclease inhibitor that interrupts a mechanism used by the virus ... represented by older neuraminidase inhibitor Tamiflu (oseltamivir). That was a $3 billion brand at its ...

Although consisting of only eight genomic segments, multiple gene-encoding mechanisms mean 11 viral ... occurs when the surface hemagglutinin and neuraminidase segments reassort between different ...

That’s a different mechanism from oseltamivir (Tamiflu), an anti-influenza medication available in the U.S. that works by blocking the virus’s neuraminidase enzyme, preventing its escape from the host ...

The proposed model for explaining the differential rate of export is compelling, going beyond the state of the art, but the experimental setup is only in partial support and further studies will be ...

Notably, the HKU5-CoV-2 strain can enter human cells by binding to the ACE2 receptor — a protein on the surface of many cells — mirroring the mechanism used by SARS ... The virus had a neuraminidase ...

What Is the FDA’s Role in Public Health? The U.S. health agency regulates the country’s foods and drugs, among other products. With the FDA’s role in drug development and nutrition policy ...

Catani and colleagues provide data on antigenic properties of neuraminidase proteins of pandemic H1N1 and show that antigenic diversity of the neuraminidase from 2009 to 2020 largely falls into two ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Nonstructural protein 1 of influenza A (NS1A) is a key virulence factor produced ...

The National Advisory Committee on Immunization (NACI) is an External Advisory Body that provides the Public Health Agency of Canada (PHAC) with independent, ongoing, and timely medical, scientific, ...

This article reviews the role of inflammation and lipid accumulation, especially low-density lipoprotein (LDL), in the pathogenesis of atherosclerosis, with more emphasis on cellular mechanisms.