Objective This study evaluated whether hypoglycemic drug metformin enhances the anti-cancer effects of cisplatin in YD-9 cells. Methodology YD-9 cells, derived from oral mucosal squamous cell ...
Brain tissues from mice in protocol 1 were analyzed by Western blot as previously described (Echeverria ... Rabbit polyclonal antibodies directed against PSD95 and phospho-Akt (Ser 473) were obtained ...
ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins
amounts of signaling proteins detected by Western blotting using the following antibodies purchased from Cell Signaling Technology: tErk (#9102) pErk (#4370), tSrc (#2109), pSrc (#6943), tAkt (#9272), ...
STAT3, MAPK (ERK1/2, JNK and p38) and PI3-AKT phosphorylation in explants was assessed by Western blot. Morphometric analysis was performed in all lung explants. Results STAT3 was expressed by ...
In amongst a clutch of discontinued phase 3 programmes in Roche's fourth-quarter results update was the news that it has stopped a study of AKT inhibitor ipatasertib as a treatment for first-line ...
Mechanistically, they suggested that PLECTIN inhibition attenuated FAK, MAPK/ERK, and PI3K/AKT signaling. Strengths: The authors generated a liver-specific Plectin knockout mouse model. By using DEN ...
This fundamental article significantly advances our understanding of FGF signalling, and in particular, highlights the complex modifications affecting this pathway. The evidence for the authors' ...
Department of Nuclear Medicine, Tianjin Key Lab of Functional Imaging & Tianjin Institute of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China North China University of ...
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