The Los Angeles Chargers are a massive +7.5 underdog ahead of their 1 p.m. ET tilt against the Buffalo Bills at Highmark Stadium on Sunday, Sept. 27. My top Chargers vs. Bills predictions and NFL picks are calling for Los Angeles covering the number in Week 3 thanks to an improved offensive effort led by quarterback Justin Herbert.

Derrick Henry has four rushing touchdowns through Baltimore's first two games.

The Browns are coming off an exciting win over the Tampa Bay Buccaneers in a game where quarterback Deshaun Watson, dare we say, looked like a competent NFL quarterback.

The Chargers had two tight ends go down with injuries, forcing them to look for reinforcements for this game.