Jaguars fans remember the last time Flacco suited up against Jacksonville, in Week 14 of 2023 for Cleveland with starting quarterback Deshaun Watson out due to a season-ending shoulder injury. Flacco threw for 311 yards, three touchdowns and one interception in the Browns’ 31-27 victory.

The Indianapolis Colts have downgraded quarterback Anthony Richardson from questionable to doubtful for the club's Week 5 matchup against the Jacksonville Jaguars. The former first-round pick was a limited participant throughout the week of practice with what the team listed as an oblique injury.

A banged-up Colts team is likely going to have to break a decade-long drought in Jacksonville without its starting quarterback, in addition to its starting center, best defensive lineman, two starting defensive ends and its best cornerback.