We developed a cell division–activated Cre-lox system for stochastic recombination of loxP-flanked loci in mice. Cre activation by frameshift reversion is modulated by DNA mismatch-repair status ...

The Cre-lox recombination method orchestrates remarkable genetic manipulations that remain a gold standard for transgenic mice.

Most analysis of gene function in biomedical research relies on the use of Cre-lox technology. Since its introduction in 1994, this technology has revolutionized biomedical science because it ...

The Cre-lox recombination method orchestrates remarkable genetic manipulations that remain a gold standard for transgenic mice. A series of rodent experiments showed that even with abundant food and ...

lox sequences in the same positions. They then used an enzyme called Cre recombinase, which connected matching lox sequences to each other, to switch out the mouse DNA for the human fragment.

One of the systems used for conditional gene inactivation is Cre/lox. "It is the gold standard for the conditional gene inactivation in mice but over time has also become quite important in other ...

PSEN1 conditional knockout (PS1 cKO) mice were generated from a Cre/lox recombination system. With this strategy PSEN1 expression is progressively eliminated from the neocortex and hippocampus ...

We have used powerful conditional “gene knockout” techniques involving the cre/lox recombinase system to create mice that lack neurotrophic factors only in a specific tissue. This allowed us to ...

They used a genetic recombination system known as Cre/lox to arrange the genes that encode the coloured proteins, lighting up only nerve cells in mice.