We developed a cell division–activated Cre-lox system for stochastic recombination of loxP-flanked loci in mice. Cre activation by frameshift reversion is modulated by DNA mismatch-repair status ...

The Cre-lox recombination method orchestrates remarkable genetic manipulations that remain a gold standard for transgenic mice. ... The resulting experimental mouse is hemizygous for Cre and ...

Most analysis of gene function in biomedical research relies on the use of Cre-lox technology. ... allows scientists to eliminate or activate the function of any gene in any cell type in the mouse.

The Cre-lox recombination method orchestrates remarkable genetic manipulations that remain a gold standard for transgenic mice. A series of rodent experiments showed that even with abundant food and ...

Hint: Precisely insert large swaths of human DNA into the mouse genome. Hint: ... Smith and his colleagues adapted a system called Cre/lox for exchanging two gene segments.

The floxed PS1 mouse was generated in C57BL/6J and 129/Sv hybrid. Availability: Available through Jie Shen. Summary. PSEN1 conditional knockout (PS1 cKO) mice were generated from a Cre/lox ...

Cre-Controlled CRISPR, the new method developed by a team of Dresden researchers led by Prof. Michael Brand, combines the benefits of the Cre/lox system with the CRISPR/Cas9 genetic scissors.

They used a genetic recombination system known as Cre/lox to arrange the genes that encode the coloured proteins, lighting up only nerve cells in mice. "By using this so-called Cre system, what ...

We have used powerful conditional “gene knockout” techniques involving the cre/lox recombinase system to create mice that lack neurotrophic factors only in a specific tissue. This allowed us to ...