Without the second gene copy to worry about, we can generate these knockout cell lines in a fairly streamlined and convenient fashion — and we can hit pretty much any gene in the genome.

With 10,000 gene targets available — 3,000 of them off-the-shelf — the knockout cell lines can be used as a model system to study the role of genes in cellular processes and drug responses ...

We provide transgene expression in mammalian cell lines using lentiviral and retroviral transduction and gene knockout and knockin using CRISPR/Cas9 technologies. 1. STABLE CELL LINE GENERATION ...

Engineer mainstream point mutation and knockout cell lines or safely and efficiently generate large complex knock-in cells for further differentiation and assay development.

Rebecca Roberts is a science writer and communicator. She earned her PhD in molecular biology from the University of the Sunshine Coast in Australia and completed a two-year postdoctoral fellowship at ...

The scientists analyzed datasets from DepMap's genome-wide CRISPR knockout screens in more than 1,200 cell lines. They noticed ... deletions within the FOCAD gene specifically caused the cells ...

This article was published by IBN, a multifaceted communications organization engaged in connecting public companies to the ...

Calidi Biotherapeutics Inc. (NYSE American: CLDI) (“Calidi”), a clinical-stage biotechnology company developing a new generation of targeted antitumor virotherapies, today announced promising ...

Down the line, the team aims to refine their protocol. “We are trying to increase the editing efficiency that we achieve,” Castiello said. She also wants to optimize delivery of the gene into the ...

Scientists have created a new gene therapy for a debilitating genetic ... The therapy worked as intended in knockout cells and was safe in wild-type mice, and also prevented death after birth ...