Objective This study evaluated whether hypoglycemic drug metformin enhances the anti-cancer effects of cisplatin in YD-9 cells. Methodology YD-9 cells, derived from oral mucosal squamous cell ...
The findings are helpful for understanding EGF/mTOR signal transduction and support a critical role for the scaffolding protein Ezrin in the upstream regulation of EGFR/AKT activity, TSC subcellular ...
Preliminary investigations suggest that Haprolid mitigates HCC growth by modulating the AKT signaling pathway. Nevertheless, the intricate dynamics by which Haprolid impedes HCC growth and its ...
Western blotting allows scientists to identify specific proteins in complex biological samples and determine relative abundance of a protein target. Rebecca Roberts is a science writer and ...
Sprague-Dawley rats with streptozotocin (STZ)-induced diabetes were treated with puffball spores to ascertain whether they accelerated wound healing.Real-time quantitative PCR, western ... AKT(1:5000, ...
phospho-Akt were measured by western blot with and without insulin stimulation. A Flag-tagged INSR expression vector (wild or mutant type) was transfected into CHO cells. For phosphorylation assays, ...
Animal pole explants were isolated at blastula stages and collected at blastula, gastrula, or early neural plate stages for western analysis ... cells showed low or undetectable phosphorylated-Akt ...
Interestingly, PHLPP-1 had no apparent effect on nuclear targeting or expression of phospho-Akt in LIF-stimulated cells. Lastly, Miyamoto el al found a 45% reduction in myocardial infarct size ...
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