Polyol pathway - Alchetron, The Free Social Encyclopedia
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Polyol pathway - Alchetron, The Free Social Encyclopedia
Also called the sorbitolaldose reductase pathway, the polyol pathway appears to be implicated in diabetic complications, especially in microvascular damage to the retina, kidney, and nerves. Sorbitol cannot cross cell membranes, and, when it accumulates, it produces osmotic stresses on cells by dra
Jun 25, 2018
Polyol Pathway and Diabetes
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Mrinal Barua | Doctor | Nutrition | Metabolism on Instagram: "Increased conversion of glucose to fructose by the polyol pathway contributes to cataract formation mainly through osmotic and oxidative stress. In hyperglycemic conditions, excess glucose is metabolized to sorbitol, which accumulates in lens cells due to its poor membrane permeability. This causes water influx, cell swelling, and disruption of lens fiber organization, leading to opacity. Simultaneously, the pathway consumes NADPH, re
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