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17:31
YouTube
Brian Daniels-Li
4.3 Structure of the TCR-MHC Complex (Immunology 2025)
The T cell receptor (TCR) recognizes antigens only when presented by major histocompatibility complex (MHC) molecules. In this video, we break down the structure of the TCR–MHC complex, showing how TCR variable regions interact with peptide–MHC, the role of CD3 signaling chains, and how CD4 and CD8 co-receptors stabilize binding. This video ...
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A crosssection of a Tcell receptor cell membrane displaying the strategic positioning of the receptors to maximize antigen detection.
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